Learning objectives
<br />
Release and Targeting of Biotechnology Drugs is an advanced course of Pharmaceutical Technology giving the required knowledge for the preparation of the dosage forms for biotech substances.<br />
Objective of the course is to provide the basis for design, development and manufacture the dosage forms that for their complexity are also called “therapeutical system”. In particular, the dosage forms suitable to carry the biotech drugs in the body will be treated. <br />
Together with the essential notions of pharmaceutical technology, the base knowledge of biopharmaceutic and pharmacokinetics will be given. In addition, the materials, mechanisms and devices adopted in the fundamental operations for drug release and targeting achievement will be treated.<br />
Prerequisites
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Course unit content
<br />
Unit operations and pharmaceutical dosage forms<br />
Bioavailability and Bioequivalence<br />
Administration routes of drugs<br />
Drug release control: story, fundamental and applications<br />
Solubility, specific surface area and dissolution rate of drugs and drug products<br />
Mass transport or diffusion: Fick law, thin film diffusion, membrane transport, free diffusion.<br />
Natural and synthetic polymers: biodegradable, cellulose derivatives, PVA, PVC, PEG, PLA, PLGA.<br />
Devices for drug release control: reservoir and matrix<br />
Drug carriers: polymer conjugates; micelles; inclusion compounds; liposomes,<br />
micro and nanoparticles.<br />
Full programme
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Bibliography
<br />
P.Colombo, P.L.Catellani, A.Gazzaniga, E.Menegatti, E.Vidale, Principi di tecnologie farmaceutiche. Editore: Casa Editrice Ambrosiana, 2004<br />
<br />
Martin, Physical Pharmacy<br />
<br />
H.C.Hansel, N.G.Popovich, L.V. Allen, Pharmaceutical Dosage Forms and Drug Delivery Systems<br />
<br />
G. Banker, C.T. Rhodes, Modern Pharmaceutics<br />
<br />
V. Lee, Peptide and Protein Drug Delivery<br />
<br />
A.T. Florence, Physicochemical Principles of Pharmacy
Teaching methods
Three written tests will be performed during the development of the course. Each one of them consists in a question requiring a free answer and a questionaire wiht multiple choice answers.
Assessment methods and criteria
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Other information
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