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Università degli Studi di Parma Università degli Studi di Parma
University of Parma
Course catalogue
Università degli Studi di Parma
course catalogue

DESIGN OF BIOTECHNOLOGICAL VACCINES AND VIRAL VECTORS UNIT B
cod. 1000269

Academic year 2008/09
1° year of course - Second semester
Professor
Academic discipline
Malattie infettive degli animali domestici (VET/05)
Field
Discipline veterinarie e riproduzione animale
Type of training activity
Characterising
20 hours
of face-to-face activities
2 credits
hub: -
course unit
in - - -
lectures timetable unavailable
exam calls

Integrated course unit module: DESIGN OF BIOTECHNOLOGICAL VACCINES

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Learning objectives

Acquisition of the current viral gene manipulation techniques relative to gene therapy.

Prerequisites

Students are required to have good knowledge of the basic molecular biology of eukaryotes and prokaryotes.

Course unit content

 Viral Vectors in gene therapy and immunotherapy <br />
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Retrovirus: <br />
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a) ! Molecular aspects of replication <br />
<br />
b) Vector structure: oncoretrovirus (MMLV) and lentivirus (HIV) <br />
<br />
c) Packaging strategies <br />
<br />
d) Targeting and pseudo-typification strategies and mechanisms (VSV-G) <br />
<br />
e) <br />
<br />
<br />
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Adenovirus: <br />
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a) Molecular aspects of replication <br />
<br />
b) Structure of Helper-Dependent vectors <br />
<br />
c) Structure of multiple-deletion Helper-Independent vectors <br />
<br />
d) Cell transduction and expression control <br />
<br />
<br />
<br />
Herpesvirus: <br />
<br />
a) &nbs! p; < /SPAN>Molecular aspects of replication <br />
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b) Structure of defective herpes vectors and Helper-Dependent amplicons <br />
<br />
c) Structure of Helper Virus-Free Type 1 Amplicon and Hybrid Amplicon vectors <br />
<br />
d) Cell transduction and expression control <br />

Full programme

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Bibliography

Bibliografia consigliata: The bibliography consists of monographs and articles taken from specialized journals as well as from a reference text: Viral vectors, basic science and gene therapy, edited by A. Cid-Arregui and A. Garcia-Carranca.

Teaching methods

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Assessment methods and criteria

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Other information

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