Learning objectives
The aim of the course is to give basic knowledge for the comprehension of causes and mechanisms of diseases. The alterations of the structures, the functions, the control mechanisms and the responses to cell injury will be studied at different levels of integration (molecule, cell, tissue and organism). This course will offer to the student some examples of laboratory diagnosis using biochemical and functional tests. Favoured by this knowledge, the student will be able to apply oneself to biomedical research and to laboratory diagnostics. <br />
The comprehension of the matter requires a good knowledge of histology, anatomy, biochemistry and physiology. <br />
Prerequisites
Physiology of organs and systems
Course unit content
<u>General Pathology</u> <br />
Introduction to pathology. Health and homeostasis. Deviation from homeostasis. <br />
CELL INJURY, ADAPTATIONS, AGING AND DEATH <br />
Causes and mechanisms of cell injury. Intracellular and extracellular accumulations. Adaptations: atrophy – hypertrophy – hyperplasia – metaplasia – dysplasia. Ageing. Cell death. <br />
GENETIC DISORDERS <br />
Monogenic and multifactorial disorders. Cromosomal alterations. Molecular diagnosis of genetic diseases. Prenatal diagnosis. Methods and applications of cell cultures in research and diagnostics. <br />
TISSUE RESPONSES TO INJURY <br />
Acute and chronic inflammation. Tissue repair – regeneration, healing, fibrosis. <br />
NEOPLASIA <br />
Classification, nomenclature and epidemiology. Morphological features of tumor cells. Benign and malignant neoplasms. Biology of tumor growth. Carcinogenesis. Malignant transformation. Tumor markers. Molecular diagnosis of cancer. <br />
<br />
<u>General Pathophysiology</u> <br />
PATHOPHYSIOLOGY OF THERMOREGULATION <br />
Fever <br />
PATHOPHYSIOLOGY OF BLOOD CELLS <br />
Hematopoiesis. Evaluation of hematopoietic function. Myeloid and lymphoid neoplasms. Plasma cell disorders. Anemias, classification, examples and laboratory diagnosis. <br />
PATHOPHYSIOLOGY OF COAGULATION <br />
Hemostasis. Laboratory evaluation of hemostasis. Bleeding disorders. <br />
PATHOPHYSIOLOGY OF BLOOD VESSELS <br />
Thrombosis. Embolism. Atherosclerosis. Ischemic cardiomyopathy. <br />
PATHOPHYSIOLOGY OF METABOLISM <br />
Diabetes mellitus <br />
PATHOPHYSIOLOGY OF LIVER <br />
Jaundice. Hepatitis. Cirrhosis. <br />
PATHOPHYSIOLOGY OF NUTRITION <br />
Full programme
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Bibliography
<p>Robbins - Pathologic basis of disease - ed. Saunders</p>
<p>Celotti - Patologia generale e fisiopatologia - ed. Edises</p>
<p>Rubin - Patologia - ed. CEA</p>
Teaching methods
Class lectures. Educational material available on line
Assessment methods and criteria
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Other information
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