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University of Parma
Course catalogue
Università degli Studi di Parma
course catalogue

PHYSICAL METHODS IN ORGANIC CHEMISTRY
cod. 03599

Academic year 2008/09
1° year of course - First semester
Professor
Academic discipline
Chimica organica (CHIM/06)
Field
Discipline chimiche industriali
Type of training activity
Characterising
32 hours
of face-to-face activities
4 credits
hub: -
course unit
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lectures timetable unavailable
exam calls
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Learning objectives

<br />The aim of the course is to give the participants a thorough knowledge of the basic and advanced tools for the structural analysis or organic compounds through monodimensional and bidimensional NMR spectroscopy. 

Prerequisites

<br />The basic knowledge of quantum mechanics (operators, wavefunctions, eigenfunctions and eigenvalues of operators) is requested although not strictly necessary.

Course unit content

<br />Comparison between the Product Operators Formalism and the Vectorial Model in the interpretation of the NMR spectroscopy experiments. Brief outline of the vectorial model. Introduction to operators. Product operators for one spin. Hamiltonians for spins and delays. Motion equation and standard rotations. Spin-echo experiment with the formalism of the product operators. Product operators for a weak-coupled two spins system. Basic concepts of the 2D NMR spectroscopy. Chemical exchange and the EXSY experiment: pulse sequence. Multiple-quantum coherences and phase cycling. 2D NMR experiments with coherence transfer mediated by J-coupling. 2D COSY and DQF-COSY spectroscopy: pulse sequences and spectra interpretation. 2D TOCSY spectroscopy: pulse sequence and spectra interpretation. Nuclear Overhauser Effect (NOE): 1D NOEdif spectroscopy and 2D NOESY and ROESY spectroscopy: pulse sequences and spectra interpretation. Hetero-correlated (HMQC and HSQC) 2D Spectroscopy: pulse sequences and spectra interpretation. Several example of structural identification of organic compounds through 2D NMR spectroscopy.

Full programme

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Bibliography

<br />P. J. Hore, J. A. Jones, S. Wimperis, NMR: The Toolkit, Oxford Chemistry Primers N.92, Oxford University Press.<br />James Keeler, Understanding NMR Spectroscopy, Wiley 2005.

Teaching methods

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Assessment methods and criteria

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Other information

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