Learning objectives
Release and Targeting of drugs is an advanced course of Pharmaceutical Technology giving the knowledge for the advanced dosage form preparation. Objective of the course is to give to the student the knowledge for designing, developing and manufacturing dosage forms that for their complexity are sometime called “therapeutical system”.
Together with the essential notions of pharmaceutical technology, the base knowledge of biopharmaceutics, pharmacokinetics and mass transport will be given. In addition, the materials, mechanisms and devices adopted in the fundamental operations for drug release and targeting achievement will be treated.
Prerequisites
Base pharmaceutical technology knowledge is required.
Course unit content
- Bioavailability and Bioequivalence
- Administration routes of drugs
- Drug delivery control: story, fundamentals and applications
- Solubility, specific surface area and dissolution rate of drugs and drug products
- Mass transport or diffusion: Fick law, thin film diffusion, membrane transport, free diffusion.
- Natural and synthetic polymers: biodegradable, cellulose derivatives, PVA, PVC, PEG, PLA, PLGA...
- Devices for drug release control: reservoir and matrix
- Drug carriers:polymer conjugates, micelles, inclusion compounds;liposomes;micro and nanoparticles;lipidic microspheres;monoclonal antibodies and immunoconjugates
Full programme
- Bioavailability and Bioequivalence
- Administration routes of drugs
- Drug release control: story, fundamental and applications
- Solubility, specific surface area and dissolution rate of drugs and drug products
- Mass transport or diffusion: Fick law, thin film diffusion, membrane transport, free diffusion.
- Natural and synthetic polymers: biodegradable, cellulose derivatives, PVA, PVC, PEG, PLA, PLGA...
- Devices for drug release control: reservoir and matrix
- Targeting: active and passive
- Drug carriers:
polymer conjugates, micelles, inclusion compounds
liposomes
micro and nanoparticles
lipidic microspheres
monoclonal antibodies and immunoconjugates
Bibliography
P.Colombo, P.L.Catellani, A.Gazzaniga, E.Menegatti, E.Vidale, Principi di tecnologie farmaceutiche. Editore: Casa Editrice Ambrosiana, 2004
Teaching methods
The teaching method is frontal didactics. Special care is addressed to the teacher/student interaction.
Assessment methods and criteria
The evaluation of the learning will be performed by written tests at the end of each month. The test consists in a free answer question and in questionaries
Other information
The teacher is available for questions on Tueasday, Wednesday and Friday, before and after the lesson time.
