Learning objectives
<p align=""justify"">The course provides basic notions for the qualitative and quantitative determination of substances of pharmaceutical interest. In particular, during the practical training the attention will be focused on the qualitative analysis of inorganic salts and on the quantitative determination of inorganic and organic analytes. </p>
Prerequisites
Prerequisite course: General and Inorganic Chemistry
Course unit content
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<div align="justify">Safety and first aid procedures in the chemical and pharmaceutical laboratory. Symbols, risk and safety phrases. Hazard chemicals handling procedures. </div>
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<div align="justify">Lab equipment and instrumentation: the analytical balance, burettes, pipettes, the pH-meter, calibration of measuring devices. </div>
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<div align="justify">Basic laboratory techniques and operations: solubilisation, dilution, concentration, desiccation, precipitation, decantation, filtration, centrifugation, solvent extraction. </div>
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<div align="justify">Introduction to Qualitative Inorganic Analysis. Preliminary Tests. Solubility. </div>
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<div align="justify">Combustion assay, flame test. </div>
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<div align="justify">Qualitative analysis in aqueous solution: reactions of main anions and cations with particular reference to inorganic or organo-metallic compounds enrolled in the Official European Pharmacopeia, analysis of acid insoluble residual. </div>
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<div align="justify">Introduction to Quantitative Pharmaceutical Analysis. Sampling. Experimental error: types of errors, precision and accuracy, expression and propagation of uncertainty. Standard and normal solutions. Volumetric and gravimetric analysis. </div>
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<div align="justify">Alkalimetry and acidimetry: preparation and standardization of solutions. </div>
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<div align="justify">Analysis of the titration curve: choice of the indicator, potentiometric determination of the final point.</div>
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</ol>
Full programme
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Bibliography
<ol>
<li>ARANEO: “Chimica analitica qualitativa. Nuovo metodo periodale”, Ambrosiana Ed. </li>
<li>BARBETTI P., QUAGLIA M.G. “L’analisi qualitativa in chimica farmaceutica e tossicologica inorganica”, Galeno Ed. </li>
<li>HOGNESS, JOHNSON, ARMSTRONG “Analisi qualitativa ed equilibrio chimico”, Piccin Ed. </li>
<li>HARRIS D.C., “Chimica Analitica Quantitativa”, Zanichelli Ed <br />
</li>
</ol>
Teaching methods
<p align="justify">The exam will consist in practical, written and oral tests. Practical exercitations during the course will be taken into due consideration</p>
Assessment methods and criteria
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Other information
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