Learning objectives
The course, divided in theoretical lessons and individual practice training, is aimed at providing the basic notions for the qualitative and quantitative determination of substances of pharmaceutical interest. In particular, during the practical training the attention will be focused on the qualitative analysis and quantitative determination of inorganic compounds.
Prerequisites
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Course unit content
<p>Safety and first aid procedures in the laboratory <br />
Symbols, risk and safety phrases. Hazard chemicals handling procedures <br />
Basic laboratory techniques and operations: solubilisation, dilution, precipitation, centrifugation, solvent extraction. <br />
Absolute and relative density; measurement of density: densimeter, picnometer and Westphal balance. <br />
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Qualitative Inorganic Analysis <br />
Lab equipment and instrumentation <br />
Preliminary Tests <br />
Solubility <br />
Qualitative analysis in aqueous solution: identification of anions and cations. <br />
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Quantitative Pharmaceutical Analysis <br />
Lab equipment and instrumentation: the analytical balance, burettes, pipettes. <br />
Experimental error: types of errors, precision and accuracy, expression and propagation of uncertainty. <br />
Sampling <br />
Standard and normal solutions. <br />
Volumetric analysis. <br />
Alkalimetry and acidimetry: preparation and standardization of solutions. Analysis of the titration curve: choice of the indicator. <br />
Redox Titrations: <br />
Permanganometry <br />
Iodometry and iodimetry <br />
Redox indicators <br />
Complexometric and chelometric titrations. EDTA: acid-base properties, effect of pH on complexation, indicators. <br />
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Full programme
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Bibliography
Araneo A. “Chimica analitica qualitativa. Metodo periodale” terza edizione, Casa Editrice Ambrosiana, Milano. <br />
Jeffery J.H., Basset J., Mendham J., Denney R.C. “Vogel Analisi Chimica Quantitativa” Casa Editrice Ambrosiana, Milano. <br />
Harris D.C. “Chimica Analitica Quantitativa” seconda edizione, Zanichelli, Bologna.
Teaching methods
Practical<em> in itinere</em> evaluations, written and oral exam.
Assessment methods and criteria
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Other information
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