Learning objectives
To provide bases of genetics in the context of environmental mutagenesis<br /><br />
Course unit content
<br /> Part 1 – DNA and mutations<br />- DNA structure, Watson and Crick model<br />- DNA replication<br />- Causes of genetic instability of DNA <br />- Spontaneous mutations <br />- Mechanisms<br />- Induced mutations and causes <br />- Mutagens and mechanisms <br />- Mutations and mutants <br />- Relationships among genotype and phenotype <br /><br />Part 3 – Mutagenesis tests <br />- Mutagens and environmental mutagens <br />- Mutagenesis tests: definitions, uses, principles <br />- Mutagenesis tests with microbes, cells, animals, plants <br />- Mutagenesis tests and genetic diseases in man <br />- Mutagenesis tests and relationships with carcinogenesis and teratogenesis tests <br /><br />Part 3 – Hypersensitivity to environmental pollutants <br />- Modes of exposure <br />- Exposure biomarkers <br />- Effect biomarkers <br />- Susceptibility biomarkers (hypersensitivity) <br />- Ecogenetic markers<br />- Correlations among biomarkers<br /><br />
Bibliography
*Genetica biochimica umana. - Harris, Harry Bologna : Zanichelli, 1972, c1974. - ix, 324 p. ; 24 cm. ((Tit. orig.: The principles of human biochemical genetics<br />*Ecogenetics : genetic predisposition to the toxic effects of chemicals / editor-in-chief Philippe Grandjean ; editorial board Dinko Kello ... et al.!. - London etc.! : Chapman and Hall, 1991. - XIV, 288 p. ; 24 cm. <br />*Test di mutagenesi. - Padova : Piccin, 1978. - 3 v. ; 20 cm. <br />*Batteri, lieviti, attivazione metabolica in vitro / Roberto Barale, Angelo Abbondandolo. - Padova : Piccin, 1978. - 62 p. : ill. ; 24 cm.<br />*Funghi filamentosi, piante, insetti, cellule di mammifero in vitro / Stefania Bonatti, Roberto Barale, Angelo Abbondandolo. - Padova : Piccin, 1978. - 68 p. : ill. ; 24 cm.<br />*Uomo, animali da laboratorio / Angelo Abbondandolo. - Padova : Piccin, 1978. - 40 p. : ill. ; 24 cm.<br />*Mutagenesi ambientale / di Nicola Loprieno. - 2. ed. - Padova : Piccin editore, c1979. - 102 p. ; 24 cm.<br /><br />
