Learning objectives
Students will acquire knowledges on microbial genomics applied to outbreak investigation, source attribution and risk assessment. Whole genome sequencing platforms and technologies will be described. Benefits of a real-time outbreak investigation and a more targeted source attribution and hazard identification/characterisation will be discussed along with major challenges and opportunities.
Prerequisites
none
Course unit content
Whole genome sequencing platforms and technologies
Introduction to microbial risk analysis
WGS and outbreak investigation (definition of outbreak, subtyping approaches, platforms for real-time outbreak investigation)
WGS and source attribution (frequency-matching, machine learning, network models)
Genome Wide Association Studies and prediction of phenotypic traits
WGS and risk assessment (pathogen typing and characterisation for hazard identification, prediction of virulence potential for dose-response relationships in hazard characterisation, prediction of phenotypic traits associated to growth/survival for exposure assessment)
Full programme
- - -
Bibliography
ppt presentations, published scientific papers
Teaching methods
Oral lectures, scientific seminaries
Assessment methods and criteria
Oral examination. Final grading of the integrated course will be an average of the scores obtained in the two course units
Other information
Participation is not mandatory but highly recommended
The professor is available to meet the students upon fixing a date by email to frederique.pasquali@unibo.it
