Learning objectives
The aim of the course is to provide students with an in-depth knowledge of the molecular mechanisms that explain the metabolic responses and the adaptation of the organism to intense and short-term physical exercise, to prolonged and constant exercise and to training, metabolism muscle and the biochemistry of training. Furthermore, the aim of the course is to provide students with recommendations for an optimal diet for athletes of various disciplines, highlighting the close link between nutrition, energy metabolism and physical response to exercise. The student is asked to understand and learn the content of the course. Attendance at the course will enable the student to acquire the appropriate skills to be able to describe, communicate effectively and comment on the most important topics of the program with independent judgment.
Prerequisites
The students will have to fulfill the prerequisites previously established in the CdS.
Course unit content
Initially the course introduces the student to the molecular organization and function of sarcomere describing the molecular action of contraction.
Metabolic interrelationships in tissues and organs: metabolism of carbohydrates, lipids and proteins. Metabolism during feeding, fasting and stress. The Skeletal Muscle, sarcomere and myofibrillar proteins: structural organization, Molecular mechanisms of nerve impulse conduction and muscle contraction. Energy for muscle contraction. Classification, properties and metabolism of muscle fibers. Distribution of the various types of fibers.
The course continues describing the function of energy substrates during different kind of physical exercise and dissecting the fatigue at molecular level.
Sources of energy in the muscle. Energy substrates present in the muscle fibers. Aerobic and anaerobic metabolism: aerobic, anaerobic a-lactate and anaerobic lactate. Effects of physical exercise on glucose transport systems and the effect of training. Carbohydrate metabolism during exercise. Lipid metabolism during exercise. Amino acid and protein metabolism during exercise. Molecular signals and regulators of muscle fatigue. Training.
Basal metabolism and metabolic balance. Nutrient principles and evaluation of energy and nutritional needs in physiological conditions and for the athlete. Healthy eating habits and eating patterns. Diet and exercise.
Full programme
Metabolic interrelationships in tissues and organs: metabolism of carbohydrates, lipids and proteins. Metabolism during feeding, fasting and stress. The Skeletal Muscle, sarcomere and myofibrillar proteins: structural organization, Molecular mechanisms of nerve impulse conduction and muscle contraction. Energy for muscle contraction. Classification, properties and metabolism of muscle fibers. Distribution of the various types of fibers. Sources of energy in the muscle. Energy substrates present in the muscle fibers. Aerobic and anaerobic metabolism: aerobic, anaerobic a-lactate and anaerobic lactate. Effects of physical exercise on glucose transport systems and the effect of training. Carbohydrate metabolism during exercise. Lipid metabolism during exercise. Amino acid and protein metabolism during exercise. Molecular signals and regulators of muscle fatigue. Training. Effects of exercise on gene expression. Miokines. High intensity, endurance and interval training. Role of hormones in regulating the different metabolic activities and their variations in relation to activity and sport. Biochemistry of the endocrine system and its regulation. Structure and classification of hormones. Receptors and mechanism of action of hormones. Second messengers. Metabolic role of hormones.
Energy and nutritional requirements of healthy subjects and in sports activities. Macro- and micronutrients. The balanced diet. Diet and sports performance. Pre-, intra- and post-competitive diet.
Bibliography
Recommended text and bibliographic sources:
Nelson DL, Cox MM: I principi di Biochimica di Lehninger, Zanichelli, Bologna.
Caldarera CM, BIOCHIMICA SISTEMATICA UMANA, 2003, Clueb
G. Federici,: Medicina di laboratorio – Ed. McGraw - Hill (ultima edizione)
Di Giulio A., Fiorilli A., Stefanelli C.: BIOCHIMICA PER LE SCIENZE MOTORIE, Editore CEA
Mougios V.: EXERCISE BIOCHEMISTRY, Human Kinetics
Don MacLaren, James Morton: Biochimica metabolica dello sport e dell'esercizio fisico; Edi ermes
Nutrizione per lo sport 1: Principi di nutrizione. Biagi, Di Giulio, Fiorilli, Lorenzini, Editrice Ambrosiana
Nutrizione per lo sport 2: Alimentazione per lo sport e la salute. Biagi, Di Giulio, Fiorilli, Lorenzini, Editrice Ambrosiana
Sito della Società Italiana di Nutrizione Umana: www.sinu.it/
Sito dell’Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione: www.inran.it
Fondamenti di Nutrizione Umana. Di A Mariani Costantini, C Cannella e G Tomassi.
Il Pensiero Scientifico Ed. Roma, 1999.
Teaching methods
The course will be held through lectures to Students either in the classroom (“in presenza”) or in synchronous-streaming (“in telepresenza”) on the Teams platform. Therefore, the opportunity of Student/Teacher interaction will be preserved both face to face and remotely, by the simultaneous use of the Teams platform.
Lectures will be supported by slide presentations, which will be available to students on the Elly platform (https://elly2020.medicina.unipr.it/).
Assessment methods and criteria
The course includes an oral test conducted with a traditional approach (oral question) in front of the examining board consisting of the course teachers. The summative judgment will be expressed with a final mark out of thirty (on a scale of 0-30).
In case of the persistence of the health emergency, the exams will be conducted remotely, as follows:
remote oral questions, through the Teams platform (guide http://selma.unipr.it/).
Students with SLD / BSE must first contact Le Eli-che: support for students with disabilities, D.S.A., B.E.S. (https://sea.unipr.it/it/servizi/le-eli-che-supporto-studenti-con-disabilita-dsa-bes)
Other information
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