Learning objectives
The course "Drug structure and action" provides basic and essential notions on the principles of medicinal chemistry. The most important structural, chemical and physico-chemical properties influencing drug action in the pharmaceutical, pharmacokinetic and pharmacodynamic phases are treated. The main targets of drug action and their mechanism are discussed.
Prerequisites
Basic notions of organic chemistry and biochemistry.
Course unit content
<p>Naming and classification of drugs. <br />
Structural, chemical and physico-chemical properties influencing drug action. <br />
Isosteres and bioisosteres. <br />
Drug-target interactions. <br />
Drug targets and their mechanism of action: <br />
· enzymes; <br />
· receptors; <br />
· nucleic acids, <br />
· lipids. <br />
Prodrugs. <br />
</p>
Full programme
- - -
Bibliography
G. L. Patrick: "An Introduction to Medicinal Chemistry"; Third Edition, Oxford University Press, Oxford, 2005. ISBN: 0-19-927500-9
Teaching methods
The end of course oral exam will cover all the topics of the course. The student has to demonstrate that he/she has understood the basic concepts of each topic.
Assessment methods and criteria
- - -
Other information
- - -
