Learning objectives
to provide the first year students with the basic concepts of classical genetics
Prerequisites
none
Course unit content
<br />Characters segregation. Mendelian genetics. Independent assortment. Gene interaction. Chromosome theory of inheritance. Genes on X chromosome. Chromosome theory of inheritance. Chromosome structure in prokaryotes and eukaryotes. Multiple alleles. Linkage and recombination. Crossing over. crossing-over. Non-mendelian inheritance. Elements of microbial genetics. Recombination in yeast. Tetrad analysis. Recombination in bacteria, transformation, conjugation, recombination in virus. Identification of the genetic material. DNA: structure and replication. RNA structure, transcription and translation. prokaryotes and eukaryotes. RNA structure, transcription and translation. The one-gene:one-enzyme theory. Multiple alleles. Spontaneous and induced mutation. Genome, chromosome and gene mutation. Structure of the gene (Benzer); complementation; cistron. Regulation of gene expression in prokaryotes. Operon Lac: negative and positive control. Setection of spontaneous or induced mutants. Selection strategy. Mutation frequency. Molecular basis of mutations. Physical and chemical mutagens. Reversion. Suppression.
Full programme
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Bibliography
- Robert J. Brooker GENETICA analisi e principi - Zanichelli <br />- Griffiths, Miller, Suzuki, Lewontin e Gelbart, Genetica, Zanichelli
Teaching methods
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Assessment methods and criteria
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Other information
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