Medical, veterinary anf pharmaceutical biotechnologies

Professor
Academic discipline: Farmaceutico tecnologico applicativo (CHIM/09)
Field: Attività formative affini o integrative
Type of training activity: Related/supplementary

14 hours
of face-to-face activities

2 credits

hub: -

course unit
in - - -

lectures timetable unavailable

exam calls

Integrated course unit module: BIOMATERIALS AND BIOCOMPATIBLE SYNTHETIC MATERIALS

Learning objectives

Main goal of the course is the understanding of the chemistry and physics of natural and synthetic polymers used in tissue engineering and drug delivery

Prerequisites

General knowledge of inorganic and organic chemistry are required

Course unit content

Natural and synthetic polymers for biomedical use.
Tridimensional polymeric scaffolds.
Chemical modification of polymers.
Solid-state manipulation.
Physico-chemical characterisation polymeric films:
hydrophilicity (contact angle, swelling index);
mechanical characteristics (elastic module, elongation to break, deformability);
porosity of tridimensional structures;
surface characteristics (roughness) by microscopy;
chemical composition of the surface.
Polymeric scaffolds as drug delivery systems.

Full programme

• Polymer definition and classification.
• Linear and crosslinked polymers, method of polymerisation and crosslinking.
• Polymer molecular weight and its determination.
• Solid state of polymers, crystalline and amorphous structure.
• Glassy and rubbery state, transition temperature.
• Polymers in solution.
• Natural and synthetic polymers used in biomedicine.
• Tridimensional structure of polymeric scaffolds.
• Chemical modification of polymers.
• Solid state manipulation.
• Physico-chemical characterisation of tridimesional polymeric structures, and films.
• Polymeric scaffolds as drug delivery systems.
• Drug release kinetics from matrix systems.

Bibliography

A. Martin, Physical Pharmacy, Fourth Edition, Lea & Febiger 1993

Bibliographic material will be distributed during the course

Teaching methods

Lectures (" CFU: 16 hours)

Assessment methods and criteria

Oral examination

Other information

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MEDICINAL PRODUCTS FOR ADVANCED THERAPY cod. 1000255