Learning objectives
The course, composed by theoretical lessons and individual practice
training, is aimed at providing the basic notions for the qualitative and
quantitative determination of substances of pharmaceutical interest. In
particular, during the practical training attention will be focused on the
qualitative analysis and quantitative determination of inorganic
compounds of pharmaceutical interest.
Prerequisites
Basic knowledge of general and inorganic chemistry
Course unit content
Safety and first aid procedures in the laboratory
Symbols, risk and safety phrases. Hazard chemicals handling procedures
Basic laboratory techniques and operations: solubilisation, dilution,
precipitation, centrifugation, solvent extraction.
Solubility and solubility product
Concentration
Density
Qualitative Analysis:
Lab equipment and instrumentation
Preliminary Tests
Qualitative analysis in aqueous solution: identification of anions and
cations.
Introduction to spectroscopic analysis
Quantitative Analysis:
Lab equipment and instrumentation: the analytical balance, burettes,
pipettes.
Experimental error: types of errors, precision and accuracy.
Sampling
Standard and normal solutions
Volumetric analysis
Choice of the indicator
Preparation and standardization of solutions
Alkalimetry and acidimetry
Redox Titrations
Complexometric and chelometric titrations
Potentiometric titrations;pH-meter
Analysis of the titration curve
Full programme
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Bibliography
Araneo A. “Chimica analitica qualitativa. Metodo periodale” Terza
edizione, Casa Editrice Ambrosiana, Milano.
Harris D.C. “Chimica Analitica Quantitativa” Seconda edizione, Zanichelli,
Bologna.
Abignente E., Melisi D., Rimoli M.G. "Principi di Analisi Quantitativa dei
Medicinali" Seconda edizione, Loghia, Napoli.
Teaching methods
Oral lessons and practical exercises in the laboratory
Assessment methods and criteria
Practical in itinere evaluations, written and oral exam.
Other information
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