Learning objectives
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This course aims to provide the informations and the scientific underground to approach correctly the main topics in Clinical Biochemistry by students of pharmaceutical sciences.<br />
This knowledge is needed especially by a professional like the chemist which is at the connection between patients and medical structures also to orientate between many specific diagnostic devices and tools for specimen’s collection, treatment and managing commonly available in the chemist shop.
Prerequisites
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There are no obligatory prerequisites, but Clinical Biochemistry is an interdisciplinary science and needs the basic knowledge in Biology, Anatomy, Physiology, Chemistry and Biochemistry
Course unit content
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Part 1. General Clinical Chemistry. <br />
Biological specimens consideration: instruction for optimal collection, treatment and conservation (avoiding pre-analytical variation).<br />
Part 2. Analysis of biological samples; analytical techniques and instrumentations. <br />
The main analytical techniques and instrumentations to evaluate the molecules of interest in Clinical Chemistry. Analytical and post-analytical variability affecting the laboratory data. Clinical laboratory quality assurance. Kits for diagnostic tests.<br />
Part 3. Current waived test.<br />
Point of care testing (POCT): use and application. Criteria for test waiving. Quality control in POCT. Implementation and monitoring of POCT. Specimen and its treatment in POCT. Places of POCT utilization. Auto-monitoring of some biochemical parameters.<br />
Part 4. Application of POCT<br />
Control of glycemia; Diabetes and patient self-monitoring. Lipid metabolism diseases; POCT for blood triglycerides, cholesterol and lipoprotein analysis; self-monitoring and cardiovascular risk.<br />
Part 5. Outline of Clinical Biochemistry<br />
Markers of function or damage of some organs and systems. Index of cytolysis, clinical enzymology. Main cardiac, hepatic, renal and tumor markers. Toxicology, therapeutic drug monitoring; sport doping and abuse substances control<br />
Full programme
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Bibliography
<p> </p>
<p>- G. Kellerman. Valori anormali di laboratorio. McGraw-Hill.<br />
- L. Spandrio. Biochimica Clinica. Ed. Sorbona – Milano. <br />
- R.A. Sacher, R.A. McPherson Interpretazione clinica degli esami di laboratorio. McGraw-Hill, New York.</p>
Teaching methods
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The final oral examination is about the topics of the course; the student needs to demonstrate to have understood and to be able to manage the essential meanings of every section of the program.
Assessment methods and criteria
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Other information
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