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Università degli Studi di Parma Università degli Studi di Parma
Second cycle degree course in
Medical, veterinary anf pharmaceutical biotechnologies
Università degli Studi di Parma
Department of Medicine and Surgery

BIOTHERMODYNAMICS
cod. 23807

Academic year 2009/10
1° year of course - First semester
Professor
Academic discipline
Chimica fisica (CHIM/02)
Field
Discipline di base applicate alle biotecnologie
Type of training activity
Characterising
16 hours
of face-to-face activities
2 credits
hub: -
course unit
in - - -
lectures timetable unavailable
exam calls

Integrated course unit module: MOLECULAR MECHANISMS OF DRUG ACTION

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Learning objectives

The course aims at providing students with the thermodynamic concepts for understanding the energy interconversion in biological systems and the interaction of ligands with biological macromolecules.

Prerequisites

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Course unit content

 The laws of thermodynamics. Application of thermodynamic principles to chemical and biological systems. Calorimetry and biocalorimetry. <br />
Thermodynamic properties of solutions and applications, phase equilibria, osmotic pressure, membrane equilibria. <br />
Chemical equilibrium, thermodynamics of chemical reactions in solution, proton binding: pH behaviour of biomolecules, binding equilibria, binding curves. <br />
Bioenergetics, molecules through membranes: transport modes, coupled reactions. <br />
Intermolecular forces, van der Waals forces, potential energy, hydrogen bond, hydrophobic interactions. <br />

Full programme

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Bibliography

- P. W. Atkins, J. De Paula, Chimica Fisica Biologica 1, prima edizione italiana, Zanichelli, Bologna, 2007. <br />
- P. W. Atkins, J. De Paula, Chimica Fisica, quarta edizione italiana, Zanichelli, Bologna, 2004. <br />
- A.G. Marshall, Biophysical Chemistry, Wiley & sons, New York. <br />
- K.E. Van Holde, Physical Biochemistry, Prentice-Hall, Englewood Cliffs. <br />
- David G. Nicholls Bioenergetics Academic press, inc. <br />
- Scientific reviews on specific topics. <br />

Teaching methods

During teaching activity the students can take two written "in itinere" tests, or, otherwise, there are written examinations on the whole syllabus during normal examination sections.

Assessment methods and criteria

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Other information

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