Learning objectives
Aim of the course is to provide a panoramic view of the various aspect of genotoxicity and in particular of the environmental genotoxic risk at which humans are subjected. The course provides a detailed overview of methodologies for monitoring human populations for signs of exposure to genotoxic agents, and monitoring the environment itself (e.g., air, water, soil).
Prerequisites
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Course unit content
Human genome Instability and DNA repair: Molecular basis of DNA alterations - Spontaneous alterations of and damages to DNA - Molecular mechanisms involved in the control of genome integrity - DNA repair in prokaryotic and eukaryotic organisms <br />
Genotoxic agents: chemical and physical mutagens – Drug metabolizing enzymes – Antimutagens <br />
Phenotypic effects of somatic mutations – Cancer genetics: cancer induction and progression pathways, genome stability. <br />
Sources of genotoxic pollutants: natural and manmade mutagens and cancerogens in: environmental samples (air, soil, water, etc), diet and drugs. <br />
Mutagenicity testing: biomarkers and biomonitoring; in vitro and in vivo mutagenicity tests. <br />
Full programme
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Bibliography
Mutagenesi ambientale a cura di Lucia Migliore Ed. Zanichelli 2004, ISBN 8808-07719-5. <br />
Tossicologia a cura di Greim H. e Deml E., Ed. Zanichelli 2000, ISBN 8808-09979-2. <br />
Teaching methods
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Assessment methods and criteria
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Other information
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