Learning objectives
To provide fundamental knowledge and understanding of the nature and mechanisms of adverse and toxic effects of drugs and foreign substances.
Prerequisites
Pharmacology and pharmacotherapy
Course unit content
General section
- Fundamentals of toxicology
- Absorption, distribution and excretion of toxic compounds.
- Biotransformation of xenobiotics
- Genetic toxicology, carcinogenicity, reproductive and developmental toxicology.
Special section
- Toxicity testing and risk assessment
- Idiosyncrasy and allergic reactions, xenobiotic interactions.
- Toxicology of pesticides, metals, solvents and vapors, household products, natural toxins.
- Environmental toxicology: air, water and soil pollutants.
- Food toxicology: food additives and contaminants.
- Antidotal therapy
- Toxicology of biotech products
Full programme
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Bibliography
CASARETT & DOULL’S: “Tossicologia: fondamenti dell’azione delle sostanze tossiche”, Ed. EMSI, Roma.
GOODMAN & GILMAN’S: “The pharmacological basis of therapeutics”
DOLARA: “Tossicologia generale ed ambientale”, Ed. Piccin, Padova.
Teaching methods
Oral lesson
Assessment methods and criteria
Oral exam
Other information
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