Learning objectives
The aim of this course is to offer to the student the opportunity of a molecular approach to the disease. Students will be able have a general view of the pathogenesis of the disease correlating the molecular alterations with alterations of cell, tissue and organ. Diagnostic possibility at molecular level will be also discussed.
Prerequisites
- - -
Course unit content
GENETIC DISORDERS
Transmission patterns of pathologic characters; Molecular basis and example of single-gene disorders; Multifactorial syndromes; Numerical and structural disorders of chromosomes
AGING AND CELL DEATH
Premature aging; Progeria; Werner syndrome; Telomerase, aging and cancer
GENETIC DISORDERS OF ERYTHROCYTE
Sickle-cell disease; Thalassemias; Erythrocyte enzyme deficiency; cytoskeleton alterations
NEURODEGENERATIVE DISEASES
Alzheimer’s disease; Parkinson’s disease; Amyotrophic lateral sclerosis; Duchenne Becker muscular dystrophy; Prion diseases; Trinucleotide repeat expansions: Fragile X syndrome, Huntington disease
MOLECULAR DIAGNOSIS OF GENETIC DISORDERS
Per- and postnatal diagnosis
NEOPLASIA
Nomenclature; Characteristics of benign and malignant cancer; Molecular basis of cancer; Biology of tumor growth; Tumor progression; Carcinogenesis; Tumor markers; Molecular diagnosis of cancer; Application of Monoclonal antibody in oncology
Full programme
- - -
Bibliography
Robbins - Pathologic basis of disease
Teaching methods
Frontal lesson
Assessment methods and criteria
Oral examination
Other information
Didactic material available on-line
