Learning objectives
The goal of the course is to provide the theoretical knowledge beyond the functioning of the various dosage forms for therapy in order to understand the way for optimizing the therapeutic efficacy of an active pharmaceutical ingredient as well as to provide the students with the theoretical and practical knowledge required for a proper compounding
Prerequisites
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Course unit content
The course concerns the modern approach to the medicine production, the composition and the characteristics of the various dosage forms as well as of the peculiarity of certain administration routes. The content of the course are also relevant to the skills for the modern and correct approach to the pharmaceutical compounding with particular emphasis to the preparations of various dosage forms and the responsibility of the Pharmacist in this respect
Full programme
First module:
Metrology
- Good Compounding Practices
-Compounding a doctor prescription
-National price of medicines
Unit operation: grinding, mixing; dissolution, filtration.
Compounding the following dosage forms:
Powders and granules;
Capsules;
Solutions;
Emulsions;
Suspensions;
Ointments;
Suppositories.
Second module:
• Drugs, dosage forms and medicines.
• Pharmacopoeia and Formulary
• Administration way and pharmacokinetics.
• Biopharmaceutical Classification System
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• Unit Operation: Crystallisation, Distillation; Drying; Lyophilisation Sterilization; granulation.
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• Pharmaceutical excipients.
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• Dosage forms: powders; granules; capsules, tablets, suppositories drops, syrups: suspensions; emulsions; ointments; eyewash; injectables; aerosols; herbal remedies.
• Stability
Bibliography
-Farmacopea Ufficiale della Repubblica Italiana, XII Edizione, Istituto Poligrafico e Zecca dello Stato, Roma (2008);
-P. Colombo, P.L. Catellani, A. Gazzaniga, E. Menegatti, E. Vidale Principi di Tecnologie Farmaceutiche, Casa Editrice Ambrosiana, Milano (2004)
-F.Bettiol, Manuale delle preparazioni galeniche, Tecniche Nuove , Milano (2010).
-Medicamenta, Cooperativa Farmaceutica Milano, VII ED. 1992;
Letture consigliate:
A.J. Winfield, R.M.E. Richards, Pharmaceutical Practice second edition, Churchill Livingstone London (1998);
Le Hir, Tecnica Farmaceutica, Edizione italiana a cura di G. Pifferi, Masson, Milano (1981).
Approfondimenti:
International Journal of Pharmaceutical compounding.
European Pharmacopoeia.
US Pharmacopoeia
Teaching methods
Frontal lectures and practice in lab
Assessment methods and criteria
Practical exam, written and oral exam
Other information
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