Learning objectives
The integrated course will provide the main knowledge on osteochondrogenesis and on the biomaterials used for bone and cartilage regeneration and repair and for general surgery, vascular surgery and surgical hemostasis. Knowledge on medical devices for advanced therapy are also provided.
Prerequisites
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Course unit content
1) Osteochondrogenesis (Module A) (5 CFU) Lecturer: Prof. Paolo Borghetti (VET/03) - [3 CFU of theoretical lessons (24 hours) + 2 CFU of praticals (16 hours)].
Theory: Structure, function and degenerative pathology of articular joints. Chondrogenesis, biomaterials for cartilage regeneration/repair.
Practicals: Tecniques for culture and differentiation of articular chondrocyte.
2)Osteochondrogenesis(Module B) (5 CFU) Lecturer: Dott. Antonio Cacchioli (VET/01) - [3 CFU of theoretical lessons (24 hours) and 2 CFu of practicals (16 hours)]
Theory: Locomotor system, bone tissue and osteogenesis, biomaterials employed in orthopaedic and dental field.Notion of legislation on animal experimentation
Practical training: Histological techniques for evaluatoin of osteointegration.
3) Medical devices for advanced therapy (2 CFU). Lecturer: Prof. Ruggero Bettini (CHIM09 - 2 CFU/16 hours of classrooom lectures)
Natural and synthetic polymers for biomedical use. Tridimensional polymeric scaffolds.
4)Biomaterials and bioprotesis. Lecturer: Dott. Luigi Bonati (MED/18) (1 CFU: 8 hours of theoretical lessons)
Biomaterials in general surgery, vascular surgery and surgical hemostasis
Full programme
1) Osteochondrogenesis (Module A) (5 CFU) Lecturer: Prof. Paolo Borghetti (VET/03) - [3 CFU of theoretical lessons (24 hours) + 2 CFU of praticals (16 hours)].
Theory:
Anatomy , histology and biomechanics of articular joints. Structure, biology and metabolism of the articular cartilage.
Physiopathology of the tissue cartilage metabolism. The molecular basis of chondrocyte differentiaiton and chondrogenesis. Biomaterials for cartilage reparing
Practicals:
Isolation of chondrocytes from articular cartilage tissue.
Adhesion and tridimensional models of primary chondrocyte culture.
Tecnique for the maintainance of the differentiation of articular chondrocytes in culture.
2)Osteochondrogenesis(Module B) (5 CFU) Lecturer: Dott. Antonio Cacchioli (VET/01) - [3 CFU of theoretical lessons (24 hours) and 2 CFu of practicals (16 hours)]
Theory:
Locomotor system: classification of bones and principles of biomechanic
Osteology:
- Forms of bony tissue
- Histogenesis
- Morphological and structural characteristics
- Deposition and remodeling dinamics
Definition and classification of biomaterials employed in orthopaedic and dental field
Experimental protocols for evaluation of osteointegration
Notions of legislation on animal experimentation
Methods for the osteintegration evaluation: bone vital markers, polarized light microscopy analysis, histochemical and immunohistochemical reactions, histological stains.
Practical training (16 hours):
The practical activity will focused on:
- Histological techniques for processing undecalcified bone tissue with implants
- Histolgical stains, Histochemical and Immunohistochemical reactions
- Observation of histological sections by polarizing light and fluorescence optical microscope
- Digitalization and image analysis.
3) Medical devices for advanced therapy (2 CFU). Lecturer: Prof. Ruggero Bettini (CHIM09 - 2 CFU/16 hours of classrooom lectures)
Natural and synthetic polymers for biomedical use.
Tridimensional polymeric scaffolds.
Chemical modification of polymers.
Solid-state manipulation.
Physico-chemical characterisation polymeric films:
hydrophilicity (contact angle, swelling index);
mechanical characteristics (elastic module, elongation to break,deformability);
porosity of tridimensional structures;
surface characteristics (roughness) by microscopy;
chemical composition of the surface.
Polymeric scaffolds as drug delivery systems.
4)Biomaterials and bioprotesis. Lecturer: Dott. Luigi Bonati (MED/18) (1 CFU: 8 hours of theretical lessons)
Biomaterials in general surgery, vascular surgery and surgical hemostasis
Topic:
Prostheses biocompatible in addominal wall surgical repair, in incisional hernias, and in addominal hernias repair.
Vasculars prostheses and patches in vascular surgery.
Hamostatic medications in abdominal, vascular, and thoracic surgery.
Bibliography
Scientific reviews, teaching materials and lab protocosl provided during lessons
Teaching methods
Classroom lectures (72 hours) and practical activity (32 hours)
Assessment methods and criteria
Oral examination
Other information
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