Learning objectives
Acquisition of essential knowledge about: Principles of anti-infective vaccinology. Relevant existing vaccines. Biotechnological vaccines: characteristics and development. Existing biotechnological tools in vaccinology. Main viral vectors for gene therapy and immunotherapy.
Prerequisites
No
Course unit content
Principles and immunological basis of vaccinology. Relevant available anti-infective vaccines (live-attenuated, killed-inactivated, subunit, purified or conjugated antigens, toxoids, recombinant) or experimental (DNA, anti-idiotypic). Biotechnological vaccines and their design: characteristics and development. Existing biotechnological vaccines (HBV, HPV, Rotavirus, polysaccharide-conjugated vaccines). Rational design. Reverse vaccinology. Recombinant bacteriophges and bacteria as vaccines and vaccine delivery veicles. Plant-based vaccines. Adjuvants and delivery systems. Viral vectors for gene therapy and immunotherapy. Retrovirus: Molecular aspects of viral replication. Architecture of following viral vectors: Oncoretrovirus (MMLV) and Lentivirus. Packaging strategies and mechanism of targeting and peseudotypization (VSV-G). Cellular transduction and expression control.
Full programme
Principles and immunological basis of vaccinology. Relevant available anti-infective vaccines (live-attenuated, killed-inactivated, subunit, purified or conjugated antigens, toxoids, recombinant) or experimental (DNA, anti-idiotypic). Biotechnological vaccines and their design: characteristics and development. Existing biotechnological vaccines (HBV, HPV, Rotavirus, polysaccharide-conjugated vaccines). Rational design. Reverse vaccinology. Recombinant bacteriophges and bacteria as vaccines and vaccine delivery veicles. Plant-based vaccines. Adjuvants and delivery systems. Viral vectors for gene therapy and immunotherapy. Retrovirus: Molecular aspects of viral replication. Architecture of following viral vectors: Oncoretrovirus (MMLV) and Lentivirus. Packaging strategies and mechanism of targeting and peseudotypization (VSV-G). Cellular transduction and expression control.
Bibliography
Lectures notes. Reviews on specific topics.
Teaching methods
Oral lessons
Assessment methods and criteria
Oral examination
Other information
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