PHARMACEUTICAL BIOCHEMISTRY
cod. 23806

Academic year 2011/12
1° year of course - First semester
Professor
Academic discipline
Biochimica (BIO/10)
Field
Discipline biotecnologiche comuni
Type of training activity
Characterising
48 hours
of face-to-face activities
6 credits
hub: -
course unit
in - - -

Integrated course unit module: INTERACTION DRUG-BIOMOLECULES

Learning objectives

The course aims at providing students with the molecular basis for the
understanding of the interaction between biological macromolecules and ligands,
with a focus on drug targets.

Prerequisites

- - -

Course unit content

PART ONE: RECOMBINANT DRUGS
Expression systems: bacteria, yeast, mammalian cells, plants and transgenic
animals
Recombinant insulin
Edible vaccines
Subunit vaccines: vaccines against HVB and HPV
Recombinant factor VIII
Recombinant Erythropoietin
ATryn (recombinant antithrombin)
Antibodies and their application in therapy

PART TWO: DRUG TARGETS
Definition of drug and drug target
Binding properties of proteins
Enzymatic catalysis
Enzymes as drug target
Reversible inhibitors
Irreversible inhibitors
Enzyme activators
Receptors as drug targets
Transmembrane channels and transporters as drug targets
DNA as a drug target
RNA as a drug target

Full programme

- - -

Bibliography

David L. Nelson, Michael M. Cox
I PRINCIPI DI BIOCHIMICA DI LEHNINGER 5 ed, ZANICHELLI

Teaching methods

LECTURES

Assessment methods and criteria

ORAL EXAM

Other information

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