Learning objectives
Through class attendance and through self-study, the student will acquire the following skills
Knowledge and understanding: The student will demonstrate knowledge of the physico-chemical bases that regulate the operation of nuclear receptors and membrane; to understand the mechanisms through which small molecules activate or block nuclear or membrane receptors
Applying knowledge and understanding: The student must show to be able to synthesize their knowledge, their ability to analyze and understand the structure-activity relationships for classes of drugs through devising and sustaining critical arguments in the field of medicinal chemistry, proving to be able to have a professional approach to discipline
In addition, the teaching aims to achieve autonomy of judgment and Communicative Abilities.
Making judgments: Students will be able during the lessons, to interact with the themes suggested by the teacher and, even with the help of the recommended texts and teaching materials, be able to make independent judgments
Communication skills: The student must be able to clearly and critically present the results of their individual calculations, demonstrating knowledge of research topics carried out during the program
Prerequisites
Organic Chemistry , Medicinal Chemistry , Biochemistry , Physiology , Pharmacology
Course unit content
1) Nuclear receptors
- classification
- structure
- molecular basis
for transcriptional
- definition of a steroid hormone
- nomenclature and chemical structure of steroid hormones
- biosynthesis of steroid hormones
- mechanism of action of steroid hormones
2) Corticosteroids
3) Female sex hormones
4) Male sex hormones
5) Hyperlipoproteinemia and cardiovascular disease
- the cholesterol and other blood lipids
- cholesterol biosynthesis
- lipoproteins
- hyperlipoproteinemias
6) HMG - CoA reductase inhibitors ( statins )
7) Medicines to treat diabetes
- type 1 diabetes
- type 2 diabetes
8) Oral hypoglycemic
Full programme
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Bibliography
Gragam L. Patrick ,
Pharmaceutical Chemicals,
III edition Edises
Teaching methods
The course will be conducted through lectures . Each lesson is a teaching module unit , in which , for each topic , are given to the student the foundation for acquiring knowledge and understanding , and to apply the knowledge and understanding to the problem treated in the unit of learning module
Assessment methods and criteria
Through an oral exam it will be ' verified that the student has successfully acquired the knowledge and understanding and the ability to apply knowledge and understanding of at least three topics covered in the course . In addition , it will be ' evaluated the independence of judgment and communication skills . The examination is only passed if the student will demonstrate a correct acquisition of skills . The vote will be formed for 30% of knowledge and understanding , 30 % of application of knowledge and understanding , 20 % of independent judgment and 20 % of communication skills .
Other information
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