Learning objectives
Basic knowledge of the mechanisms underlying, tissue response to injury (inflammation, hemostasis, repair), genetic diseases, and tumors. Fundamentals of immune response and its alterations, with a peculiar emphasis on transfusion medicine and on subjects of particular relevance for obstetricians.
Prerequisites
Basic elements of chemistry, biochemistry, anatomy and physiology.
Course unit content
1. The blood: composition and pathophysiology. Anemia. 2. Inflammation:Events of acute inflammation; Exudate; Types of exudate; Phagocytosis; Chronic inflammation and granulomas; Abscesses and ulcers;
Chemical mediators of inflammation; Systemic effects of inflammation; Tissue repair. 3. Hemostasis:Phases and events of the hemostatic response; Hemorrhagic disorders; Thrombosis and embolism; Infarction. 4. Genetic disorders: Mutations; Single gene diseases; Examples ofautosomic dominant, autosomic recessive and X-linked disorders; Multifactorial disorders (malformations); Cytogenetic disorders. 5. The diabetic syndrome. Gestational diabetes. 6. Tumors: Classification and nomenclature; Benign and malignant tumors; Tumor etiology; Fundamentals in molecular oncology; Invasivity and metastasis; Pathogenesis of neoplastic diseases; Grading and staging. 7. Immunology: innate and adaptive immunity; Antigens and Antibodies. Ag-Ab interaction; Lymphocyte receptors; The Major Histocompatibility Complex (MHC) and Ag presentation; Functional anatomy of the immune response; Lymphocyte activation and effector functions; Primary and secondary reaction. Principles of vaccination. Immune response to infections. 8. Immunopathology: Hypersensitivity. Primary and secondary immunodeficencies. HIV infection. 9. Blood groups. AB0 system. Rh system. The hemolytic disease of the newborn.
Full programme
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Bibliography
Maier e Mariotti. Elementi di Patologia Generale e Fisiopatologia. McGrawHill.
Milano
Teaching methods
Oral interactive lessons with iconographic support
Assessment methods and criteria
Oral examination
Other information
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