COSMETIC PRODUCTS - INNOVATIVE DRUG DELIVERY SYSTEMS
cod. 1004479

Academic year 2016/17
4° year of course - First semester
Professor responsible for the course unit
SANTI Patrizia
integrated course unit
10 credits
hub: PARMA
course unit
in - - -

Course unit structured in the following modules:

Learning objectives

The objective of module 1 is the acquisition of the basic knowledge relative to functional cosmetics and cosmetic technology, both traditional and more innovative. The module gives the basic notions on the main raw products of cosmetic interest, on their functions, on the formulative techniques of the most relevant categories of cosmetics, as well as on the stability controls on finished products. The course covers also the European Regulatory Guidelines for Cosmetics, with particular regards to labeling and safety.
The purpose of module 2 is to acquire a deep-rooted knowledge of the fundamental principles of the controlled drug delivery and innovative formulations (both marketed and in-development) and to develop the ability to apply these principles to different kind of formulations and administration route. A further aim of the course is to provide the students the tools for the elaboration of the information given so as to integrate them into their knowledge.

The expected learning outcomes are:
1. Knowledge and understanding: understanding of the functional mechanisms of the skin. Acquisition of the notions relative to functional cosmetics and to cosmetic technology. Ability to use the specific language and the correct terminology for cosmetic ingredients. have acquired specific knowledge on mechanisms, materials, processes and formulations.
2. Applying knowledge and understanding: capability to recognize the function of each excipient of a given cosmetic product and the possible interactions. Capability to formulate the main categories of cosmetic products (solutions, creams, lotions, detergents). Be able to compare the innovative formulations with the traditional ones.
3. Communication skills: ability to use the specific language for this specialistic discipline. Be able to present the characteristic of a cosmetic product also to a non-expert audience. Be able to present (orally or in writing) the topics studied in a clear way and using a correct technical language.
4. Making judgements: the capability to evaluate the quality of a cosmetic product as a function of its composition and its packaging. Be able to highlight, for every innovative formulation/administration route, potentialities, limits and impact on patient therapy.
5. Learning skills: capability to connect the different subjects studied among them and with the basic disciplines. Capability of continuous education, through the scientific publications in the field of cosmetology and pharmaceutical technology.

Prerequisites

Knowledge of pharmaceutical technology is required.

Course unit content

The contents of module 1 are:
Functions of cosmetic products: hygiene, eutrophy, aesthetic
Anatomy and physiology of the skin
Cosmetic raw materials: active moieties and excipients
Silicones for cosmetic use
Vehicles for cosmetic formulations: solutions, emulsions, suspensions
Innovative cosmetic formulations: liposomes, nanoparticles, multiple emulsions and microemulsions
Skin moisturizers
Skin care products
Skin Detergents
Cosmetic products for hair care
Skin aging
New active moieties: alfahydroxyacids
Vitamines in cosmetic
Effect of UV radiation on the skin: UV filters
Make-up products
Deodorants, Antiperspirants and Perfumes
Cosmetic for skin whitening
Stability of cosmetic formulations
European Regulatory Guidelines for Cosmetics

The contents of module 2 are:
The first lecture of the course presents the rationale of the innovative pharmaceutical formulations and highlight the background needed to deal with this course. The program is the following:
General topics
• INTRODUCTION: INNOVATIVE PHARMACEUTICAL FORMULATIONS AND CONTROLLED RELEASE
• BIOAVAILABILITY – ABSORPTION
• POLYMERS FOR CONTROLLED DRUG DELIVERY
• DIFFUSIONE AND DISSOLUTION
Innovative formulations
• RESERVOIR
• MATRICES
• OSMOTIC SYSTEMS
• GASTRORETENTIVE SYSTEMS
• COLON DELIVERY
• MUCOADHESION
• MICROPARTICLES
• NANOPARTICLES
• LIPOSOMES
• HYDROGELS
Alternative administration routes
• TRANSDERMAL DRUG DELIVERY
• BUCCAL DRUG DELIVERY
• OCULAR DRUG DELIVERY
• ORAL ADMINISTRATION OF PEPTIDE AND PROTEINS

Full programme

The contents of module 1 are:
Functions of cosmetic products: hygiene, eutrophy, aesthetic
Anatomy and physiology of the skin
Cosmetic raw materials: active moieties and excipients
Silicones for cosmetic use
Vehicles for cosmetic formulations: solutions, emulsions, suspensions
Innovative cosmetic formulations: liposomes, nanoparticles, multiple emulsions and microemulsions
Skin moisturizers
Skin care products
Skin Detergents
Cosmetic products for hair care
Skin aging
New active moieties: alfahydroxyacids
Vitamines in cosmetic
Effect of UV radiation on the skin: UV filters
Make-up products
Deodorants, Antiperspirants and Perfumes
Cosmetic for skin whitening
Stability of cosmetic formulations
European Regulatory Guidelines for Cosmetics

The contents of module 2 are:
The first lecture of the course presents the rationale of the innovative pharmaceutical formulations and highlight the background needed to deal with this course. The program is the following:
General topics
• INTRODUCTION: INNOVATIVE PHARMACEUTICAL FORMULATIONS AND CONTROLLED RELEASE
• BIOAVAILABILITY – ABSORPTION
• POLYMERS FOR CONTROLLED DRUG DELIVERY
• DIFFUSIONE AND DISSOLUTION
Innovative formulations
• RESERVOIR
• MATRICES
• OSMOTIC SYSTEMS
• GASTRORETENTIVE SYSTEMS
• COLON DELIVERY
• MUCOADHESION
• MICROPARTICLES
• NANOPARTICLES
• LIPOSOMES
• HYDROGELS
Alternative administration routes
• TRANSDERMAL DRUG DELIVERY
• BUCCAL DRUG DELIVERY
• OCULAR DRUG DELIVERY
• ORAL ADMINISTRATION OF PEPTIDE AND PROTEINS

Bibliography

A.V., Manuale del Cosmetologo, Ed. Tecniche Nuove (Milano)
G.PROSERPIO, "Le basi della cosmetologia", Ed. SEPEM, Milano.
BONADEO“ Prodotti Cosmetici, cosmetología e tecnología cosmetiche” Ed. Librería Cortina (Milano)
Principi di tecnologie farmaceutiche, P. Colombo, P.L. Catellani, A. Gazzaniga, E. Menegatti, E. Vidale, Casa Editrice Ambrosiana Ed. 2004
Since some topics are not present in the book, specific texts (availabe at the library of the Department of Pharmacy) will be suggested.

Teaching methods

The course is organized with frontal lectures. The first lecture presents the rationale of the innovative pharmaceutical formulations and highlight the background needed to deal with this course. Then, general topics such as bioavailability and bioequivalence, dissolution, diffusion, polymers, controlled release are presented. Finally, the different pharmaceutical formulations and alternative delivery routes are explained in detail.

Assessment methods and criteria

The final examination is a written test and is organized so as to evaluate:
-the knowledge of the topic treated during the course
-the ability to understand and elaborate information
-the ability of applying general concepts to specific subjects
-the ability to relate the different topic studied with the knowledge acquired in the previous courses
-the pertinence of the written language (in terms of clarity and accuracy)

In particular he/she should:
a) pass an exam (either oral or written), during the official dates established by the Dipartimento di Farmacia (Module of cosmetic products, weight 50% of the overall grade);
b) pass an exam (either oral or written), during the official dates established by the Dipartimento di Farmacia (Module of innovative pharmaceutical formulations, weight 50% of the overall grade);
the overall grade);

The grade, expressed in thirtieths, will be based on the following criteria:
1. knowledge and comprehension (theoretical and practical) capability of the subjects studied;
2. making judgements ability
3. communication skills and appropriate use of the technical language;
4. ability to learn.

Other information

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